Nights 13-16 then being held from Monday May 24-Thursday May 27.
The Play-Offs, where the top four players from the league table contest the semi-finals and final, will then take place on Friday May 28.
The PDC will continue to liaise with the relevant authorities with regards to the potential for a live crowd in Milton Keynes during the 2021 season, with any information to be announced once available at pdc.tv/tickets.
Confirmation of the May dates in Milton Keynes means that all ticket holders for 2021 Unibet Premier League venues will see their bookings moved to the equivalent 2022 event, or be eligible for a refund from their point of purchase.